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WebNov 1, 2024 · REPAIR (NCT05425862) is phase I study assessing the combination of pidnarulex (CX-5461), a drug blocking RNA polymerase I transcription, in combination with talazoparib in an attempt to leverage synergistic effects of replication stress and activation of DNA damage response ultimately leading to cancer cell death [86]. WebPredicting inhibitors for SARS-CoV-2 RNA-dependent RNA polymerase using machine learning and virtual screening Elix, Inc. elix-inc.com 12 law and order season 5 episode 2
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