Phosphoswitch
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Phosphoswitch
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WebJan 6, 2024 · Creation of this phosphodegron is regulated by a phosphoswitch that is also implicated in temperature compensation. However, in vivo evidence that this phosphodegron influences circadian period is lacking. Here, we generated and analyzed PER2-Ser478Ala knock-in mice. The mice showed longer circadian period in behavioral analysis. WebFeb 20, 2024 · Thus, RSK1 CTT operates as an autoregulated phosphoswitch: its phosphorylation at specific sites affects its protein-binding capacity and its conformational dynamics. These biochemical feedbacks, which form the structural basis for the rapid dissociation of ERK2-RSK1 and RSK1-PDZ substrate complexes under sustained …
WebJan 9, 2024 · Protein homeostasis (proteostasis) is crucial to the maintenance of neuronal integrity and function. As the contact sites between neurons, synapses rely heavily on precisely regulated protein-protein interactions to support synaptic transmission and plasticity processes. Autophagy is an effective degradative pathway that can digest … WebThe phosphoswitch is a design feature of the clock Summary Period (PER) protein phosphorylation is a critical regulator of circadian period, yet an integrated understanding of the role and interaction between phosphorylation sites that can both increase and decrease PER2 stability remains elusive.
WebApr 30, 2024 · The phosphoswitch leads to two pools of PER2, one less stable due to degron phosphorylation and the other more stable due to FASP phosphorylation … WebMay 11, 2024 · We uncover a lipid-dependent phosphorylation cascade that connects membrane-composition-based cellular signalling with plant growth and patterning by regulating morphogenetic auxin fluxes. Owing to...
WebJan 17, 2024 · A phosphoswitch at acinus-serine 437 controls autophagic responses to cadmium exposure and neurodegenerative stress Authors Nilay Nandi # 1 , Zuhair Zaidi # 1 , Charles Tracy 1 , Helmut Krämer 1 2 Affiliations 1 Department of Neuroscience, UT Southwestern Medical Center, Dallas, United States.
WebOct 3, 2015 · This ‘phosphoswitch’ leads to two alternative fates for PER2: increased stability or increased degradation. The researchers report that this phosphoswitch is sensitive to changes in temperature and metabolic signals and so it fine-tunes clock speed as needed. Usually, the rate of a biochemical reaction increases as the temperature rises, so ... irish boundary commission reporthttp://xmpp.3m.com/de+shaw+research+paper porsche next 字体WebMay 19, 2024 · Mutation of a PER2 phosphodegron perturbs the circadian phosphoswitch Casein kinase 1 (CK1) plays a central role in regulating the period of the circadian clock. … porsche newsroom ukWebOct 1, 2015 · A Period2 Phosphoswitch Regulates and Temperature Compensates Circadian Period. Graphical Abstract Highlights. dPER2 degradation follows three-stage kinetics, … irish boundary commission report mapWebNational Center for Biotechnology Information porsche newport newsWebA Phosphoswitch Regulates PER2 Degradation We and others have shown that there are two phosphorylation sites, the FASP and the β-TrCP site, regulating stability of mammalian PER2 (Figure 1) ( 35, 37 ). irish boutique long grove ilWebIn this paper, we found ensure PER is required for the reactivation of CRY-mediated transcriptional repression. Thus, PER might regulate circadian rhythm through YELL. In the phosphoswitch model (Narasimamurthy et al., 2024), PER2 had either phosphorylated with the β-TrCP site (S478) alternatively FASP site (S659). PER2 phosphorylated at S478 ... irish boutique crystal lake il