Parkin antibody cell signaling
WebSelect appropriate Parkin antibodies for your research by isotype, epitope, applications and species reactivity. To the left of the product names in the table below, indicates those antibodies for which a 10 µg trial size SAMPLE is available free of charge. Web4 Jun 2014 · PINK1 and parkin expression were confirmed by immunoblot analysis with an anti-parkin antibody Prk8 (Cell Signaling Technology) or an anti-PINK1 antibody D8G3 …
Parkin antibody cell signaling
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Web3 Jul 2014 · Parkin, the ubiquitin ligase that is mutated in Parkinson’s disease, regulates the clearance of damaged mitochondria through selective autophagy (mitophagy). Here, Hollville et al. show that Parkin-dependent mitophagy is regulated by members of the Bcl-2 family, which are more commonly known for their ability to regulate apoptotic cell death. WebResults for parkin antibodies 1,733 products found Reagent type. Antibodies (1,733) Biochemicals (2) Experimental Models (17) Kits (129) ... 2132 is a primary antibody from …
Web13 Apr 2024 · Additionally, Yu et al. demonstrated that SIRT3 deficiency exacerbates the streptozotocin-induced impairment of mitophagy and dysfunction in cardiomyocytes due to suppressed SIRT3-FOXO3a-Parkin signaling . SIRT3 is a key player in the antioxidant pathway of the UPRmt and may also act as a synchronous activator of the UPRmt and … Web27 Mar 2014 · Confocal microscopy was performed on LCC9 cells treated with 100 nM ICI and either transfected with GFP-LC3 or incubated with a PINK1 antibody, parkin antibody, or mitotracker-RFP. As shown in Figure 6C when mitophagy is stimulated by ICI treatment, mitochondria localize with LC3, PINK1, and parkin. Moreover, LC3 also co-localizes with …
WebParkin is a protein of 465 amino acids with an amino-terminal ubiquitin domain and a carboxy-terminal RING-box (1). In the case of autosomal recessive juvenile Parkinsonism (AR-JP), deletions have been found in the gene on chromosome 6 encoding the protein Parkin (2). Sequence: O60260 PRKN_HUMAN: Protein BLAST With NCBI / ExPASy / Uniprot Web3 Mar 2012 · These results suggest that Parkin-mediated mitophagy in neurons is a much slower process than in other cell types reported. Treating HeLa cells with 10µM CCCP or SH-SY5Y cells with 20µM CCCP can induce Parkin association with mitochondria in ~80% of cells within 1–2 hr [ 9 – 11 , 17 ].
WebPhospho-Parkin (Ser65) Antibody recognizes transfected levels of Parkin protein only when phosphorylated at Ser65. Species Reactivity: Human Source / Purification Polyclonal …
WebPolyclonal antibodies are produced by immunizing animals with a synthetic phospho-peptide corresponding to residues surrounding Ser65 of human ubiquitin protein. Antibodies are … two player studios robloxWebThe Parkin mitochondrial recruitment assay cell line is an in vitro model of Parkinson's disease developed by Creative Biolabs; it includes U2OS cell lines stably expressing the following structures: a. Green fluorescent protein (tGFP) fused to mitochondrial targeting sequence (MTS) derived from the subunit VIII of human cytochrome C oxidase. b. tallest building in gothamWebParkin is a protein of 465 amino acids with an amino-terminal ubiquitin domain and a carboxy-terminal RING-box (1). In the case of autosomal recessive juvenile Parkinsonism (AR-JP), deletions have been found in the gene on chromosome 6 encoding the protein … A Protein Modification Resource. PhosphoSitePlus ® is an online systems … Antibody Cocktail (5) Antibody Cocktail Kit (12) Antibody Duet (91) Antibody … Antibody Duet (88) Antibody Sampler Kit (347) Assay Kit (42) Blocking Peptide … Custom Antibody Conjugation; Bulk Quantities and Lot Reservations; Learn & … Here are answers to the most frequently asked questions. If for any reason you … two player tabletop simulator games