WebHelmut Haning,ab Carles Giró-Mañas,c Victoria L. Paddock,c Christian G. Bochet,db Andrew J. P. White,c Gerald Bernardinelli,b Inderjit Mann,e Wolfang Oppolzer ‡ b and Alan C. Spivey *cb Author affiliations Abstract Two syntheses of the Amaryllidaceae alkaloid clivonine ( 1) are described. WebJun 17, 2015 · Accordingly, HNE is a potential target for the treatment of pulmonary diseases such as chronic obstructive pulmonary disease (COPD), acute lung injury (ALI), acute respiratory distress syndrome (ARDS), bronchiectasis (BE), and pulmonary hypertension (PH). HNE inhibitors should reestablish the protease–anti-protease balance.
Q4 2024 - in vivo Pharmacology Services Pharmaron 5
WebOct 7, 2010 · Dr. Helmut Haning. Bayer Schering Pharma AG (Germany) Search for more papers by this author. Dr. Andreas Schall, Dr. Andreas Schall. Bayer Schering Pharma AG (Germany) Search for more papers by this author. Dr. Helmut Haning, Dr. Helmut Haning. Bayer Schering Pharma AG (Germany) WebJun 29, 2015 · Specifically, the methyl sulfone substituent was strategically positioned to accomplish optimal interaction with the S2 pocket of HNE. The clinical candidate, BAY 85-8501, exhibited efficacy in a rodent model of acute lung injury and is currently being tested for the treatment of pulmonary diseases. pasta con seppie e gamberetti
Helmut Haning – Independent – Freiberuflich LinkedIn
WebApr 11, 2024 · Dr. Helmut Haning has been working in the field of medicinal chemistry for many years and has led several successful drug projects: MR antagonist Finerenone, HIF PH inhibitor Molidustat, FGFR... WebHelmut Haning - Inventor. We have 11 US Patents with Helmut Haning listed as an inventor. Helmut Haning Publications. Us Patents. Triazolotriazinones And The Use … WebMar 25, 2002 · All compounds of the imidazo[5,1-f] 1, 2, 4 triazin-4(3H)-one type mentioned above are highly cGMP-PDE 5 selective and show IC 50 values for PDE 3 and PDE 4 greater than 500 nM.Summary. We have shown that with the imidazo[5,1-f] 1, 2, 4 triazin-4(3H)-one heterocyclic system, highly potent inhibitors of cGMP-metabolizing PDE 5 can … pasta con speck e gamberetti