Dichloromethylene diphosphonate

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August undefined, 2024

WebTesticular macrophages were selectively eliminated with dichloromethylene diphosphonate-containing liposomes (Cl2MDP-lp) to study the role of these cells in the repopulation of Leydig cells after treatment with ethylene dimethane sulfonate (EDS). Right testes were injected with Cl2MDP-lp to deplete macrophages and left testes were … WebIt is shown ultrastructurally that intravenously injected and liposome-entrapped dichloromethylene diphosphonate (DMDP) causes marked damage to marginal zone macrophages in the mouse spleen which finally results in the elimination of these cells.

Role of phagocytic macrophages in induction of contact …

Web오늘 하루 그만보기 . p-issn 2287-8696; e-issn 2288-744x; kci; 홈으로 tsl thrusters

Elimination of phagocytic cells in the spleen after intravenous ...

WebDMDP is ingested by phagocytic cells when entrapped in liposomes. Once phagocytized the liposomal membranes are digested and the drug is released into the cell and is ready for action. In vitro, even low doses of liposome-entrapped DMDP caused an significant reduction in cell numbers. WebUveitis is characterized by inflammatory lesions of intraocular structures. It is one of the important manifestations in patients with Reiter’s syndrome, an inflammatory arthritis, which is caused by enteric infection with bacteria, including Salmonella typhimurium. Corticosteroids remain the most frequently used therapies against uveitis associating … WebJul 27, 2013 · INTRODUCTION. Dichloromethylene diphosphonate (DMDP) is clinically employed for the treatment of osteolytic bone diseases. When encapsulated in … phimmoi it

Use of Dichloromethylene Diphosphonate in Metastatic Bone …

Diphosphonate, Dichloromethylene Drug Information, Uses, Side …

WebThe daily subcutaneous administration of (dichloromethylene)diphosphonate (clodronate) to 3-day-old normal inbred Wistar-Furth rats for 30 days produces osteopetrotic bone … WebDichloromethylene diphosphonate can be used for temporary elimination of macrophages in the spleen when administered after entrapment in liposomes. No comp Elimination of … tsl thundersportWebPhosphonic acid, (dichloromethylene)bis-, disodium salt CH2Cl2Na2O6P2 CID 73554303 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, … tsl tlaxcala

"WebJul 30, 2012 · A single intra-articular injection of liposomes encapsulating the drug dichloromethylene diphosphonate (CL 2 MDP) in the mouse knee joint caused selective elimination of synovial lining cells. Depletion of cells occurred within a few days as evidenced by light microscopic, electron microscopic and immunohistochemical studies. " - Dichloromethylene diphosphonate

Dichloromethylene diphosphonate

Alveolar macrophages regulate neutrophil recruitment in …

WebIt is shown ultrastructurally that intravenously injected and liposome-entrapped dichloromethylene diphosphonate (DMDP) causes marked damage to marginal zone … WebExplore the latest full-text research PDFs, articles, conference papers, preprints and more on EAE. Find methods information, sources, references or conduct a literature review on EAE

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WebNov 1, 1984 · Outre leur action remarquable dans la maladie osseuse de Paget, les diphosphonates sont très efficaces dans le traitement des hypercalcémies dont l'origine osseuse est presque toujours essentielle. Dans les hypercalcémies malignes, l'EHDP, le CL2 MDP et l'APD, les trois diphosphonates testés chez l'homme font chuter la calcémie … WebJul 21, 1994 · Dichloromethylene diphosphonate (Cl2MDP), encapsulated into liposomes, is known to eliminate splenic and hepatic macrophages. In the present study we investigated the time course of the effects of i.v. injected Cl2MDP-liposomes on macrophage function in rats from 2 h to 14 days postinjection.

WebRats received a single intravenous injection with liposome-encapsulated dichloromethylene diphosphonate (C12MDP). This treatment resulted in the … WebDichloromethylene diphosphonate (MDPCl2) encapsulated in multilamellar liposomes was selectively incorporated by macrophages, immediately transferred to lysosomes, …

WebSigma-Aldrich. 233183. Clodronate, Disodium Salt - CAS 88416-50-6 - Calbiochem. A non-amino, chloro-containing bisphosphonate that acts as a potent inhibitor of osteoclast-mediated bone resorption. WebLiposome-encapsulated dichloromethylene diphosphonate (clodronate) is known to deplete macrophages. We examined the effect of clodronate on xenoreactive antibody production and xenograft rejection. Hamster cardiac grafts were transplanted into Lewis rats. Clodronate (4 mL/kg) was injected intravenously on the day before transplantation.

Web匡德宣，王文广，孙晓梅，代解杰(中国医学科学院/北京协和医学院医学生物学研究所树鼩种质资源中心，云南省重大传染 ...

WebSep 1, 1996 · Dichloromethylene diphosphonate (MDPCl 2) encapsulated in multilamellar liposomes was selectively incorporated by macrophages, immediately transferred to … tsl toolboxWebDepletion of AM by liposome-encapsulated dichloromethylene diphosphonate is shown to cause severalfold enhancement in systemic absorption of IgG and human chorionic gonadotropin after intratracheal instillation in rats. Lowering the doses of IgG delivered to the lungs alleviates local degradation and results in a dramatic increase in systemic ... phimmoi john wickWebJan 15, 2003 · Liposomally encapsulated clodronate (dichloromethylene diphosphonate) has previously been found to be a potent antimacrophage agent. It … phimmoi john wick 4WebDisodium (dichloromethylene)di phosphonate. Molecular Formula CCl 2 Na 2 O 6 P 2; Average mass 286.841 Da; Monoisotopic mass 285.835358 Da; ChemSpider ID 19958758 phimmoi lord of the ringsWebIn this study, we demonstrated that tracheal insufflation of liposome-encapsulated dichloromethylene diphosphonate (Cl2MDP-liposome) selectively depleted AMs in … phimmoi hobbs and shawWeb暨南大学,数字图书馆. 开馆时间：周一至周日7:00-22:30 周五 7:00-12:00; 我的图书馆 tsl tonesWebKC-depletion abolished the hepatic interleukin-6 (IL-6) and interleukin-10 (IL-10) mRNA synthesis and decreased hepatic expression of tumor necrosis factor-alpha (TNF-alpha), hepatocyte growth factor (HGF) and transforming growth factor-beta1 (TGF-beta1) mRNA after PH, as was assessed by reverse-transcriptase polymerase chain reaction (RT-PCR). tsl topek southern ltd