Web2 days ago · Molecular docking of metal oxides with nsP3 elucidates the binding of A/N/Z-3, thereby inhibiting one of the replication proteins of chikungunya virus. • Metal/metal oxide (Ag/NiO) and ternary mixed metal oxides (Ag 2 O/NiO/ZnO) nanocomposites were assessed for antiviral efficacy against CHIKV through various in vitro assays. • WebJun 16, 2024 · In this study, we determined the mechanism of action by which the serotonin receptor agonist 5-NT controls CHIKV infection. Using time-of-addition and entry bypass assays, we found that 5-NT predominantly inhibits CHIKV in the early phases of the replication cycle, at a step prior to RNA translation and genome replication.
Discovery of berberine, abamectin and ivermectin as antivirals ... - PubMed
WebJun 27, 2024 · These results suggested that IFI16 has an impact on the CHIKV replication cycle, at least, in the early stage of the virus replication cycle. Open in a separate window. Figure 4. IFI16 restricts CHIKV infection in an early stage of infection. Vero cells were transfected by pIFI16 for 24 h before being infected by CHIKV at MOIs of 0.1 and 1. WebNov 20, 2024 · Here, we used the wild type CHIKV Caribbean strain and an engineered mutant harboring a deletion in the 3'UTR to dissect the interactions of virus variants with the anatomical barriers that impede transmission during the replication cycle of the virus in Aedes mosquitos. Compared to the 3'UTR mutant, we observed that the wild type virus … frank c martin reviews
Replication cycle of chikungunya: A re-emerging arbovirus
Web2 days ago · Cellular uptake of metal oxide-based nanocomposites and targeting of chikungunya virus replication protein nsP3. Author links open overlay panel Pooja Bhatia a 1, Vedita Anand Singh b 1, Ruchi Rani b, Mala Nath a ... While nsP3 is an essential component of the RNA replication process, its biochemical aspects in the virus life … WebMay 31, 2024 · Abstract. Alphaviruses are globally distributed and predominately transmitted by mosquitoes. Aedes species are common vectors for the clinically important alphaviruses—Chikungunya, Sindbis, and Ross River (RRV) viruses—with Aedes aegypti also being a vector for the flaviviruses dengue, Yellow Fever, and Zika viruses. frank cnc machine service